Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. April 2nd, 2019 Current Open Clinical Trials . If you do have symptoms, these may include pain under your ribs or in your abdomen on the right side of your body, and general symptoms, such as loss of appetite and nausea. When a person is diagnosed with lung cancer or faces a treatment decision, it is important to explore all options. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Challenges in lung cancer clinical trials: a European perspective. Conventionally fractionated radiation therapy delivers smaller doses of radiation therapy over time and may kill more tumor cells and have fewer side effects. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Location: 263 locations, This randomized phase II / III trial studies how well giving maintenance chemotherapy with or without local consolidation therapy works in treating patients with stage IV non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. We know it’s a worrying time for people with cancer, we have information to help. But early diagnosis of lung cancer has proved challenging, even in people at high risk of the disease, such as current or former heavy smokers. Leaders in advancing lung cancer treatment The UCI Chao Family Comprehensive Cancer Center is a leader in first-in-human trials of targeted therapies PD-L1 amplified tumors 50. Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12 / 19 / 2017) 24. Giving maintenance chemotherapy and local consolidation therapy together may work better than maintenance chemotherapy alone in treating patients with stage IV non-small cell lung cancer. Radiation therapy, such as stereotactic body radiation therapy, uses special equipment to position a patient and deliver radiation to tumors with high precision. New York esophageal squamous cell carcinoma 1 (NY-ESO-1) and cancer testis antigen 2 (LAGE-1a) antigens are tumor-associated proteins that have been found in several tumor types. Desmoid tumors 28. This causes cancer cells to divide more rapidly. These drugs target specific genetic mutations that can underlie a particular cancer. Location: 25 locations, This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types, including advanced urothelial carcinoma (UC) (including bladder, renal pelvis, ureter, urethra), renal cell carcinoma (RCC), castration-resistant prostate cancer (CRPC), non-small-cell lung cancer (NSCLC), triple negative breast cancer (TNBC), ovarian cancer (OC), endometrial cancer (EC), hepatocellular cancer (HCC), gastric cancer / gastroesophageal junction cancer / lower esophageal cancer (GC / GEJC / LEC), colorectal cancer (CRC), head and neck (H&N) cancer, and differentiated thyroid cancer (DTC). Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Pancreatic adenocarcinoma is not eligible 9. Sarcomatoid carcinoma of lung 12. Receiving additional care from the clinical trial staff. Some trials look at how people respond to a particular treatment and what side effects might occur. Objectives: In patients with advanced epidermal growth factor receptor mutation-positive (EGFRm+) non-small cell lung cancer (NSCLC), first-line afatinib significantly improved progression-free survival (PFS) and objective response vs. platinum-doublet chemotherapy in the phase III LUX-Lung 3 and LUX-Lung 6 trials, and significantly improved PFS, time to treatment … Show your support for the 7 million Australian men, women and children battling a debilitating and often fatal lung disease. Chordoma (closed to accrual 11 / 29 / 2018) 31. To find out more about Australian Cancer Trials, please follow the link below. Providing the most reliable information about advances in lung cancer research – or scientific discoveries dealing with lung cancer – to assist the lung cancer patient and caregiver community is our priority. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) The trials include: Clinical Trial: Relapsed or Refractory Small Cell Lung Cancer. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. Your gift, no matter how big or small, will support life-changing research, support services and advocacy for those affected by this neglected disease. Research is looking into all aspects of lung cancer and aims to improve tests, treatment, and ways of coping with symptoms and side effects. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Location: 28 locations, This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I / II lymph node-negative (T1 to T3N0M0) NSCLC. 2,3 Although screening with chest radiography improves survival from the time of lung cancer … Part 2A of the study will evaluate the safety and tolerability of dostarlimab at fixed doses of 500 mg administered every 3 weeks (Q3W) and 1000 mg administered every 6 weeks (Q6W). Three exploratory single-agent cabozantinib (SAC) cohorts may also be enrolled with UC, NSCLC, or CRPC subjects. Effective from 4 November 2020 the Australasian Lung Cancer Clinical Trials Group (ALTG) has discontinued operations. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. The purpose of this trial is to find out if the addition of pembrolizumab to usual chemotherapy is better or worse than usual chemotherapy alone for non-small cell lung cancer. Stereotactic radiosurgery, also known as stereotactic ablation radiation therapy, is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. The purpose of this study is to test the safety and effectiveness of radiation therapy followed by atezolizumab and find out what side effects, if any, it has on patient's non-small cell lung cancer. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. For patients or family members seeking information about lung cancer please visit our website or contact our free Lung Cancer Support Nurse Telehealth Service on the freecall number 1800 654 301. These panels directly helped Novartis lung cancer research programs, including the introduction of a new targeted therapy for non-small cell lung cancer, Tabrecta® (capmatinib), and an ongoing investigation involving canakinumab (ACZ885). Gestational trophoblastic disease (GTD) 47. When a person is diagnosed with lung cancer or faces a treatment decision, it is important to explore all options. 1 Early detection has been shown to reduce disease-specific mortality for breast cancer and colorectal cancer. Learn more about immunotherapy and lung cancer. Research into new immunotherapies and new ways to use these treatments is ongoing. A joint initiative between the National Health and Medical Research Council and the Department of Industry, Innovation and Science to provide information and resources to consumers, health care providers, researchers and industry about clinical trials. Location: 414 locations, This phase II LUNG-MAP treatment trial studies how well selpercatinib works in treating patients with RET fusion-positive non-small cell lung cancer that is stage IV or has come back (recurrent). Maintaining Movement home-based exercise program, “My treatment now is via a type of chemotherapy called targeted therapies. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. The clinical trials on this list are for non-small cell lung cancer treatment. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. Dose escalation will be based on ascending weight-based dose levels (DLs) of dostarlimab and will continue until the maximum tolerated dose (MTD) is reached or may be stopped at any dose level up to the highest dose of 20 milligrams per kilograms (mg / kg) based on emerging safety and PK / PDy data. Location: 53 locations, This phase III trial compares sublobar resection (surgery to remove a portion of a lobe) and stereotactic ablative radiotherapy to see how well they work in treating patients with stage I non-small cell lung cancer. Here’s the latest news in lung cancer research that the Lung Cancer Foundation of America staff has curated for our community. Giving pembrolizumab with or without chemotherapy may shrink the tumor in older patients with non-small cell lung cancer. Due to the nature of this study design, some tumor cohorts may complete enrollment earlier than others. It has been designed to provide Australians with consumer-friendly information about current cancer clinical trials. Lung cancer is the #1 cause of cancer deaths in the U.S. Find survival rates for different types & stages of lung cancer, their meanings & how they’re calculated here. 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